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KMID : 0370220120560040268
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Yakhak Hoeji
2012 Volume.56 No. 4 p.268 ~ p.273
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Ponciri Fructus Extract Induces Lipogenesis through Transcription Factor SREBP-1 Activation
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Kim Dae-Sung
Jeon Byoung-Kook
Mun Yeun-Ja
Lee Ghang-Tai
Lee Kun-Kuk
Woo Won-Hong
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Abstract
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This study was to explore the lipogenic effect by ethanol extract of ponciri fructus (EPF) and possible molecular mechanisms in sebocyte. When SZ95 sebocyte cell line were treated with the EPF, lipid droplets were accumulated in the majority of cells. EPF increased expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the SZ95 cells. EPF augmented expression of PPAR-β and PPAR-γ but not that of PPAR-α. These results suggest that EPF induces lipogenesis in SZ95 cells through SREBP-1, PPAR-β and PPAR-γ activations.
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KEYWORD
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Ponciri fructus, lipogenesis, SREBP-1, PPARs, sebocyte
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